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Welcome to the Tian Lab
2026
13. A Molecular Pump for the Synthesis and Diversification of Mechanically Planar Chiral Rotaxanes.
H. Zhang, S. Sheng, P. S. Y. Long, M. Wan, Z. X. Khoo, A. Li, H. N. Duong, S. Zhang, L. Zhang, and C. Tian*. Nat. Commun. 2026, AIP.
2025
12. Spatial Assembly of Mechanically Planar Chiral Rotaxanes on Rationally Designed Cavitands.
L. Xia, W. Hong, C. Tian*, and Y. Zhu*. Angew. Chem., Int. Ed. 2025, e20251592.
11. Expanding the Chemical Space of Mechanically Interlocked Peptides (MIPs) via Rational Design and Metabolite Profiling.
A. Li†, H. Zhang†, N. B. Nazri, M. Wan, and C. Tian*. JACS Au 2025, 5, 4845.
10. Programmable molecular dethreading towards tunable drug release.
S. Sheng†, Y. Li†, R. R. Y. Lee, Y. Gao, H. Han, Z. Wan, C. Owh, C.-A. M. Y. Chua, Z. Y. Chong, N. W. H. Ng, W. Tang, and C. Tian*. Nat. Commun. 2025, 16, 9390.
9. Development of Embryonic Stem Cell-derived Cardiomyocytes and Application of Fluorescence Probe Substrate for Characterization of CYP2J2.
X. Zhu, Y. K. Soh, M. Wan, J. K. S. Pang, W. L. Leow, C. Tian*, B. S. Soh*, E. C. Y. Chan*. Drug Metab. Dispos. 2025, 53, 100053.
2022
8. Mechanically planar chiral rotaxanes through catalytic desymmetrization.
M. Li; X. L. Chia; C. Tian*; Y. Zhu*. Chem 2022, 8, 1.
Doctoral and postdoctoral work
7. Transamidation Driven Molecular Pumps
L. Binks†; C. Tian†; S. D. P. Fielden; I. J. VItorica-Yrezabal; D. A. Leigh*. J. Am. Chem. Soc. 2022, 144, 15838.
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6. Collective total syntheses of cytochalasans and merocytochalasans
H. Zhang; J. Zhang; R. Bao; C. Tian; Y. Tang*. Tetrahedron Chem. 2022, 100022.
5. Sequence-Selective Decapeptide Synthesis by the Parallel Operation of Two Artificial Molecular Machines
J. Echavarren†; M. A. Y. Gall; A. Haertsch†; D. A. Leigh*; J. T. J. Spence†; D. J. Tetlow; C. Tian†. J. Am. Chem. Soc. 2021, 143, 5158.
4. Single-step enantioselective synthesis of mechanically planar chiral [2]rotaxanes using a chiral leaving group strategy
C. Tian†; S. D. P. Fielden†; B. Pérez-Saavedra; I. J. Vitorica-Yezabal; D. A. Leigh*. J. Am. Chem. Soc. 2020, 142, 9803.
Highlighted in Synfacts, 2020, 16, 0917.
3. Weak functional group interactions revealed through metal-free active template rotaxane synthesis
C. Tian†; S. D. P. Fielden†; G. F. S. Whitehead, I. J. Vitorica-Yrezabal; D. A. Leigh*. Nat. Commun. 2020, 11, 744.
Featured in Nat. Commun. Focus: Nanoscale & Supramolecular Chemistry.
Highlighted in Synfacts, 2020, 16, 0405.
2. Total Syntheses of Asperchalasines A-E
R. Y. Bao; C. Tian; H. Y. Zhang; Z. G. Wang; Z. Dong; Y. H. Li; M. H. Gao; H. L. Zhang; G. Liu*; Y. F. Tang*. Angew. Chem. Int. Ed. 2018, 57, 14216.
1. Total Syntheses of Periconiasins A-E
C. Tian; X. Q. Lei; Y. H. Wang; Z. Dong; G. Liu*; Y. F. Tang*. Angew. Chem. Int. Ed. 2016, 55, 6992.
Highlighted in Synfacts, 2016, 12, 0660.
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