To see a world in a grain of sand
And a heaven in a wild flower,
Hold infinity in the palm of your hand
And eternity in an hour.
— William Blake
Our mission: Make and use functional molecules to address problems in drug discovery.
Small molecules have critical roles at all levels of biological complexity and have served as powerful probes in biology and as drugs in medicine. Our general research focuses on the synthesis and applications of functional molecules, specifically biocompatible molecular machines and mechanically interlocked molecules, which can perform sophisticated and useful tasks in biological systems. Our effort will be directed towards:
1) developing new synthetic strategies for mechanically interlocked molecules (like rotaxanes and catenanes)
2) creating novel molecular machines which are compatible with biological systems
3) investigating biomedical application of molecular machines